Answer by igor rochev for miktex does not find STIX2Math.otf font
The font file has been renamed to STIXTwoMath-Regular.otf recently. I guess the package fontsetup should be updated. (I cannot comment due to low reputation, so I post this as answer.)
View Articlemiktex does not find STIX2Math.otf font
latest updated MiKTex does return:e:\miktex-portable\texmfs\data\miktex\log\miktex-maketfm.log! Font TU/STIX2Math.otf(1)/m/n/12=[STIX2Math.otf]/OT at 12.0pt not loadable: Metric (TFM) file or installed...
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